Elucidation of the physiologically distinct subunits of troponin in greatly facilitated our understanding of cardiac contraction. By exploiting cardiac-restricted epitopes within these proteins, one of the most successful diagnostic tests to date has been developed:
The continuing advances in the biochemical research for the discovering an ideal biomarker for diagnosing myocardial injury have led to discovery cardiac Troponin, a biochemical gold standard for myocardial necrosis. Further with advances in the immunoassay techniques, the 99th percentile cutoff value of cardiac troponin required for the diagnosis of myocardial infarction decreased, with the latest available ultrasensitive cardiac troponin assay capable of measuring level as low as 0.
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